Detailed view for PF3D7_0407900

Basic information

TDR Targets ID: 3855
Plasmodium falciparum, AAA family ATPase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.1167 | Length (AA): 667 | MW (Da): 77811 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0017111   nucleoside-triphosphatase activity  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
206 646 1e32 (A) 21 458 22.00 0 1 0.77 0.15
381 607 2ce7 (A) 151 376 35.00 0 1 0.81 -1
20 194 4uos (A) 2 179 19.00 0.62 0.35 0.498969 -0.94
31 181 4u5a (C) 47 238 23.00 0.39 0.35 0.371987 -0.73
239 328 2za2 (A) 4 104 36.00 0.87 0.5 0.265733 0.13
367 665 3d8b (A) 377 671 40.00 0 1 0.846876 -0.31
372 667 4l15 (A) 297 587 40.00 0 1 0.952578 -0.55
382 568 1lv7 (A) 144 335 35.00 0 1 0.69616 -0.82
387 662 4lcb (A) 93 360 41.00 0 1 0.782593 -0.35
393 529 3hws (A) 78 246 31.00 0.0005 1 0.493197 -0.04
20 194 4uos (A) 3 179 21.00 0.18 0.53 0.55925 -1.31
198 645 4ko8 (A) 17 462 24.00 0 1 0.883637 0.74
239 323 3n3m (A) 4 104 36.00 0.75 0.04 0.319799 -0.13
362 657 3d8b (A) 377 668 42.00 0 1 0.90053 -0.39
367 662 4l15 (A) 297 587 40.00 0 1 0.95653 -0.55
376 602 2ce7 (A) 151 376 35.00 0 1 0.7583 -0.41
377 563 1lv7 (A) 144 335 35.00 0 1 0.698877 -0.82
551 642 3mhv (C) 297 413 17.00 0.02 0.67 0.203873 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, sporozoite, Sporozoite, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127068)

Species Accession Gene Product
Arabidopsis thaliana AT2G45500   AAA-type ATPase-like protein
Arabidopsis thaliana AT3G27120   P-loop containing nucleoside triphosphate hydrolases superfamily protein
Babesia bovis BBOV_I000400   ATPase, AAA family domain containing protein
Brugia malayi Bm1_02420   ATPase, AAA family protein
Brugia malayi Bm1_53365   ATPase, AAA family protein
Candida albicans CaO19.7558   potential AAA family ATPase similar to S. cerevisiae SAP1 (YER047C)
Caenorhabditis elegans CELE_C24B5.2   Protein SPAS-1, isoform B
Caenorhabditis elegans CELE_F32D1.1   Protein FIGL-1
Cryptosporidium hominis Chro.50096   AAA family ATPase
Cryptosporidium parvum cgd5_2790   katanin p60/fidgetin family with AAA ATpase
Dictyostelium discoideum DDB_G0287165   AAA ATPase domain-containing protein
Dictyostelium discoideum DDB_G0268334   hypothetical protein
Drosophila melanogaster Dmel_CG3326   CG3326 gene product from transcript CG3326-RB
Drosophila melanogaster Dmel_CG5977   spastin
Echinococcus granulosus EgrG_001005200   fidgetin protein 1
Entamoeba histolytica EHI_036890   ATPase, Vps4 oligomerisation domain containing protein
Echinococcus multilocularis EmuJ_001005200   fidgetin protein 1
Homo sapiens ENSG00000021574   spastin
Homo sapiens ENSG00000132436   fidgetin-like 1
Leishmania braziliensis LbrM.15.0500   katanin-like protein,serine peptidase, Clan SJ, family S16, putative
Leishmania donovani LdBPK_150520.1   katanin-like protein
Leishmania infantum LinJ.15.0520   katanin-like protein,serine peptidase, Clan SJ, family S16, putative
Leishmania major LmjF.15.0500   katanin-like protein,serine peptidase, Clan SJ, family S16, putative
Leishmania mexicana LmxM.15.0500   katanin-like protein,serine peptidase, Clan SJ, family S16, putative
Loa Loa (eye worm) LOAG_05931   fidgetin protein
Loa Loa (eye worm) LOAG_04996   ATPase
Mus musculus ENSMUSG00000035455   fidgetin-like 1
Mus musculus ENSMUSG00000024068   spastin
Neospora caninum NCLIV_055880   ATPase, AAA family protein, related
Oryza sativa 4339999   Os06g0130000
Oryza sativa 9271031   Os12g0443800
Plasmodium berghei PBANKA_1005500   AAA family ATPase, putative
Plasmodium falciparum PF3D7_0407900   AAA family ATPase, putative
Plasmodium knowlesi PKNH_0305900   AAA family ATPase, putative
Plasmodium vivax PVX_000850   AAA family ATPase, putative
Plasmodium yoelii PY02232   ATPase, AAA family, putative
Saccharomyces cerevisiae YPL074W   putative AAA family ATPase YTA6
Saccharomyces cerevisiae YER047C   putative AAA family ATPase SAP1
Schistosoma japonicum Sjp_0049080   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma mansoni Smp_002810   fidgetin like-1
Schmidtea mediterranea mk4.010616.00  
Schmidtea mediterranea mk4.002854.04   Fidgetin-like protein 1
Schmidtea mediterranea mk4.010616.01   Fidgetin-like protein 1
Schmidtea mediterranea mk4.001181.02   Probable spastin homolog spas-1
Trypanosoma brucei gambiense Tbg972.3.1190   AAA ATPase, putative,Spastin, putative
Trypanosoma brucei gambiense Tbg972.5.2570   hypothetical protein, conserved,serine peptidase, Clan SJ, family S16, putative
Trypanosoma brucei Tb927.3.1440   Spastin, putative
Trypanosoma brucei Tb927.5.1870   metalloprotease, putative
Trypanosoma congolense TcIL3000_0_25690   Spastin, putative
Trypanosoma congolense TcIL3000_0_15540   Spastin, putative
Trypanosoma congolense TcIL3000_0_08200   metalloprotease, putative
Trypanosoma cruzi TcCLB.508533.30   metalloprotease, putative
Trypanosoma cruzi TcCLB.509437.50   Spastin, putative
Trypanosoma cruzi TcCLB.509233.70   AAA ATPase, putative
Toxoplasma gondii TGME49_302150   ATPase, AAA family protein
Toxoplasma gondii TGME49_312310   ATPase, AAA family protein
Theileria parva TP02_0917   AAA family ATPase, putative
Trichomonas vaginalis TVAG_339190   spastin, putative

Essentiality

PF3D7_0407900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.1870 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.1870 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.1870 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.1870 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.3.1440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.1440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.1440 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.1440 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F32D1.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F32D1.1 Caenorhabditis elegans slow growth wormbase
CELE_F32D1.1 Caenorhabditis elegans sterile wormbase
PBANKA_1005500 Plasmodium berghei Dispensable plasmo
TGME49_312310 Toxoplasma gondii Essentiality uncertain sidik
TGME49_302150 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0407900 (Plasmodium falciparum), AAA family ATPase, putative
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